Dab tsi yog txoj haujlwm ntawm DNJ?

Taw qhia rau DNJ

 

1.1 Kev Txhais Lus thiab Cov Qauv ntawm DNJ

{{0 {}} deoxynirojircojirisjirisjiris (DNJ), ib qho kev sib txuas ua ke, tau cais ua polyhydroxylated alkaloid. Nws yog tus cwj pwm los ntawm nws tus qauv tshwj xeeb uas zoo ib yam uas muaj cov piam thaj, nrog kev zam tsis tau muaj cov pab pawg hydroxyl ntawm lub c -1 txoj haujlwm. Cov qauv txheej txheem no peculority pab dnj los cuam tshuam nrog enzymes koom nrog carbohydrate metabolism, ua rau nws muaj nuj nqis molecuel nyob hauv thaj chaw tshuaj lom.

 

1.2 Qhov chaw ntawm DNJ

DNJ yog feem ntau pom nyob rau ntau qhov chaw cog, feem ntau muaj nyob rau hauv nplooj ntawm mulberry ntoo (Morus Alba L.). Lwm qhov chaw cog ntoo suav nrog qee hom noob taum thiab txiv hmab txiv ntoo. Cov nplooj ntawv mulberry, tshwj xeeb, tau kawm ntau yam rau nws cov ntsiab lus DNJ siab, uas ua rau nws muaj qhov zoo tshaj plaws ntuj zoo tshaj plaws rau cov khoom siv tawm thiab ua lag luam.

 

 

Kws pharmacological zog ntawm DNJ

 

2.1 hypoglycemic cuam tshuam

DNJ siv nws qhov kev cuam tshuam hypoglycemic los ntawm inhibiting kev ua si ntawm -glucosidase enzymes. Cov enzymes no yog lub luag haujlwm rau kev rhuav tshem cov carbohydrates rau hauv cov suab thaj uas yooj yim, xws li piam thaj. Los ntawm inhibiting lawv cov kev txiav txim, DNJ qeeb qeeb ntawm cov piam thaj kom haum rau hauv cov hlab ntshav, yog li pab tswj cov ntshav cov ntshav qab zib postprandial. Qhov txheej txheem no ua rau DNJ muaj kev kho tus neeg sawv cev rau kev tswj hwm hom 2 mob ntshav qab zib.

 

2.2 Cov Tshuaj Tiv Thaiv

Kev tshawb fawb tau pom tias DNJ muaj cov khoom siv antiviral tseem ceeb tiv thaiv ntau yam kev sib cuam tshuam nrog cov proteined ntawm cov protein, suav nrog tus kab mob khaub thuas. Los ntawm kev cuam tshuam cov txheej txheem no, DNJ muaj peev xwm ua kom zoo rau qhov kis tau tus kab mob no hauv tus tswv.

 

2.3 Cov Khoom Siv Antitumor

Cov kev tshawb fawb tau qhia tias DNJ cov kev ua haujlwm ntawm kev ua haujlwm tshawb fawb txog qee yam mob qog noj ntshav, xws li mob qog nqaij hlav cancer. Cov antector cuam tshuam los ntawm DNJ yog xav tias cuam tshuam nrog nws lub peev xwm los hloov cov mob qog nqaij hlav cancer, thiab kev tuag ntawm tes (thiab inhibit anastasis. Cov khoom no ua rau DNJ cov lus cog tseg rau kev txhim kho ntawm cov tshiab cancer kws kho mob.

 

2.4 Lwm cov txiaj ntsig kev noj qab haus huv

Ntxiv rau nws tus kheej hypoglycemic, tshuaj tua kab mob, thiab cov tshuaj antitumor, DNJ tau pom tias muaj lwm yam txiaj ntsig kev noj qab haus huv. Piv txwv li, nws tuaj yeem pab txo cov ntshav lipid, txo qhov mob, thiab txhim kho kev tiv thaiv kev muaj zog. Cov kev pab cuam no txhawb nqa cov txiaj ntsig ntau yam kev noj qab haus huv muaj peev xwm tsim tau rau tus neeg saib xyuas kev kho mob ntau yam rau ntau yam kev khomob.

 

DNJ hauv nplooj

 

3.1 Mulberry nplooj ua cov nplua nuj ntawm DNJ

Mulberry nplooj tau pom ntev tau lees paub tias yog qhov chaw nplua nuj ntawm DNJ, ua rau nws yog qhov tseem ceeb ntawm kev rho tawm thiab kev tsim khoom DNJ thiab tshuaj noj qab haus huv. Lub siab dnj cov ntsiab lus ntawm mulberry nplooj, txuas nrog lawv cov kev nplua mais thiab yooj yim, tau ua rau lawv xaiv qhov uas nyiam tshaj plaws rau kev siv cov txheej txheem kev lag luam.

 

3.2 cov hau kev tawm thiab ua kom huv si

Cov kev rho tawm ntawmDNJ Mulberry nplooj ExtractLos ntawm cov nplooj mulberry cuam tshuam ntau kauj ruam, suav nrog cov khoom lag luam raw, rho tawm, thiab ua kom huv. Cov hau kev tawm nquag muaj xws li cov dej rho tawm, cov kuab tshuaj extraction, thiab ultrasonic tawm. Kev tshem dej tawm yog qhov feem ntau thiab ib puag ncig phooj ywg, thaum daws cov kuab tshuaj ntxiv siv cov roj teeb organic tau tawm tsam ntau dua. Ultrasonic rho tawm, ntawm qhov tod tes, siv cov tshuab ultrasonic ultrasonic txhawm rau txhim kho cov kev txuag hluav taws xob.

 

Purification ntawmDNJ Mulberry nplooj ExtractFeem ntau yuav siv cov tswv cuab chromatography, xws li ion txauv cov chromatography thiab adsorption chrataphy. Ion txauv cov qauv chromatography siv cov resins rau xaiv los khi khi thiab cais DNJ los ntawm lwm yam hauv kev rho tawm. Adsorption chromatographaphy, ntawm qhov tod tes, siv adsorption resins rau xaiv adsorb thiab desorb raws nws affinity rau lub resin.

 

3.3 Tsoos Kev Siv Ntawm Mulberry nplooj nyob rau hauv cov tshuaj

Mulberry nplooj muaj keeb kwm ntev ntawm kev siv tshuaj suav tshuaj, uas lawv tau siv los kho ntau yam kev mob ntshav, suav nrog cov ntshav qab zib, cuam tshuam, thiab o. Kev siv ib txwm siv ntawm cov nplooj mulberry yog qhov ua tau zoo rau lawv cov ntsiab lus siab DNJ thiab lwm yam cov tebchaw xyoob.

 

 

Daim ntawv thov DNJ hauv cov tshuaj niaj hnub

 

4.1 Kev kho mob ntshav qab zib

Muab nws cov kev mob siab ntsws, DNJ muaj peev xwm muaj peev xwm ua rau kho ntshav qab zib, tshwj xeeb yog hom 2 ntshav qab zib. Dnj-based kho cov neeg sawv cev tuaj yeem muab txhais tau tias zoo rau cov ntshav qab zib los ntawm kev nqus cov piam thaj los ntawm kev noj haus. Ntxiv mus, DNJ tau pom tias txhawm rau txhim kho cov insulin rhiab heev thiab txhim kho cov kev zais ntawm insulin, uas txuas ntxiv pab txhawb rau nws qhov kev cuam tshuam hypogemiccemic.

 

4.2 Muaj peev xwm ua kev kho mob tawm tsam

Cov tshuaj tua kab mob ntawm DNTJ ua rau nws muaj kev sib tw ua rau kev tiv thaiv kab mob los ntawm kev kho cov kab mob glycosylation ntawm cov protein.

 

4.3 Cov kev cia siab hauv kev kho mob cancer

Cov khoom siv antitumor ntawm DNJ hais tias nws tuaj yeem tsim tawm mus rau hauv kev kho mob cancer tshiab, tshwj xeeb rau kev kho mob qog nqaij hlav cancer. Dnj-raws li kev kho mob cancer tuaj yeem muab cov txhais tau zoo ntawm kev txhim kho lub voj voog ntawm cov qog nqaij hlav cancer, tab tom ua kua dej paug, thiab inhibiting anastasis.

 

Tag

 

5.1 Cov ntsiab lus ntawm DNJ lub zog thiab kev siv

DNJ, ib qho tshwm sim polyhydated alkaloxylated alkalox, tau pom muaj ntau yam ntawm cov chaw muag tshuaj muaj zog, suav nrog kev ua tshuaj kho mob, suav nrog cov khoom siv hluav taws xob, suav nrog cov khoom tshuaj tiv thaiv kab mob, thiab cov tshuaj tiv thaiv kab mob. Cov khoom siv no ua rau tus neeg sib tw rau kev txhim kho cov neeg sawv cev rau kev kho mob ntshav qab zib, kab mob kis, thiab mob cancer.

 

5.2 Cov Lus Qhia Yav Tom Ntej rau Kev Tshawb Nrhiav thiab Kev Loj Hlob

Qhov muaj peev xwm ntawm DNJ hauv cov tshuaj niaj hnub no, thiab kev tshawb fawb ntxiv thiab kev txhim kho yog xav tau kom meej nws tus kheej lub peev xwm. Yav tom ntej kev tshawb fawb yuav tsum tsom mus rau kev ua kom zoo thiab ua kom tiav cov txheej txheem ntawm DNJ, nrog rau kev ntsuas kev nyab xeeb thiab kev ntsuas kev nyab xeeb thiab kev ua haujlwm hauv chaw kuaj mob. Ntxiv mus, tshawb nrhiav cov kev cuam tshuam ntawm DNJ nrog lwm tus neeg kho mob thiab txhim kho cov kev kho mob DNJ tuaj yeem muab txoj kev tshiab rau kev kho cov mob tshiab.

 

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