Oleanicic Acid thiab Plab Kev Noj Qab Haus Huv: Cov txiaj ntsig zoo thiab Synergistic cuam tshuam nrog cov tshuaj aspirin

Nquag Cheebtsam ntawm Oleanic Acid

 

Oleanolic Acidyog PenacthClic triterpenoid uas tshwm sim ua cov kua qaub dawb lossis ua aglycone hauv daim ntawv glycosidic. Nws yog feem ntau muab los ntawm cov nroj tsuag xws li tshij Eure Eurea (txiv ntseej), ligthustrum lucidum (glossy privet), thiab lwm yam tshuaj ntsuab. Cov khoom siv hluav taws xob muaj txiaj ntsig ntawm cov txheej txheem oveanicic, uas tso cai rau nws los cuam tshuam nrog cov kab mob ntawm tes, mob, thiab paug. Nws cov xwm Hydrophobic ua rau nws nqus tau nyob rau hauv lub plab zom mov hauv plab hnyuv, qhov chaw nws muaj peev xwm siv nws cov txiaj ntsig zoo.

 

 

Puas yog Alanicic Acid txhim kho kev noj qab haus huv?

 

Kev hloov kho ntawm plab microbiota
Oleanicic Acid tau pom tias muaj plab zom mov microbiota muaj pes tsawg leeg los ntawm kev txhawb nqa kev loj hlob ntawm cov kab mob muaj mob thaum ua rau muaj kev phom sij. Kev tshawb fawb qhia tau tias nws tuaj yeem txhim kho lub xub ntiag ntawm Lactobacillus thiab Bifidobacterium hom, uas pab txhawb kom txhim kho kev zom thiab kev tiv thaiv kab mob. Los ntawm kev txhawb nqa microbiome sib xyaw kom tsis txhob muaj mob dysbiosis, ib qho xwm txheej txuas rau ntau yam tsis muaj mob plob (IBS) thiab mob plab zom mov (IBD).

 

Ntxiv dag zog rau txoj hauj lwm kev tiv thaiv txoj hmoo
Ib qho tseem ceeb hauv plab kev noj qab haus huv yog kev ncaj ncees ntawm txoj hnyuv hnyuv, uas txwv tsis pub cov tshuaj tiv thaiv kab mob los ntawm cov hlab ntshav. Oleanicic Acid tau pom tias muaj protein ntau cov protein xws li occludin thiab claudin, txo txoj hnyuv permeability. Cov nyhuv no pab rau hauv kev tiv thaiv cov pa tsw qab, ib qho xwm txheej cuam tshuam nrog mob o thiab mob autoimmune auto.

 

 

Anti-inflammatory thiab antioxidant thaj chaw
Mob mob ntev yog ib qho tseem ceeb pab rau cov plab tsis muaj kev cuam tshuam.Oleanolic AcidKev cuam tshuam los tiv thaiv kev cuam tshuam los ntawm inhibing pro-inflaming cytokines xws li tnf-,}}, thiab} {4}}. Tsis tas li ntawd, nws cov khoom tiv thaiv antioxidant pab pab neutralize dawb radicals uas ua rau oxidative kev ntxhov siab, ntxiv txo cov mob hauv lub plab.

 

Kev tiv thaiv tawm tsam cov mob plab zom mov thiab mob plab
Cov kev tshawb fawb tau pom tias cov kua roj ntsha Oleanolic tuaj yeem tiv thaiv cov roj plab thiab mob plab zom mov thiab ua kom muaj kev tiv thaiv mucosal ntau dhau los thiab txhim kho kev tiv thaiv mucosal. Nws kuj mitigates rwj tsim los ntawm kev txhawb nqa mucus ntau lawm thiab txo lub zog helysobacacter pylori kev ua kom zoo, kev ua rau mob siab.

 

Cov nyhuv ntawm Alanicic Acid ua ke nrog tshuaj aspirin

 

Txo ntawm cov tshuaj aspirin-induced pais plab
Ib qho ntawm qhov tseem ceeb tshaj plaws ntawm cov tshuaj aspirin kev kho yog nws lub peev xwm los ua kev puas tsuaj rau lub plab zom mov. Kev tshawb fawb qhia tias Alanolic acid tuaj yeem tawm tsam cov nyhuv no los ntawm kev txhawb nqa cov plab zom mov thiab cuam tshuam oxidative kev ntxhov siab. Nws lub peev xwm los txhim kho mucus zais cia muab cov kev tiv thaiv tiv thaiv cov tshuaj aspirin-rau khaus khaus.

 

Txhim kho los tiv thaiv kev tiv thaiv
Ob tus aspirin thiab ooanolic acid exert anti-inflammatory cuam tshuam, tab sis lawv cov kev sib xyaw ua ke yuav tsim cov kev cuam tshuam sauv. Thaum cov aspirin inhibits cyclooxygenase (cox) enzymes kom txo cov roj av los ntawm ntau txoj hauv kev, suav nrog kev hais lus teb ntxiv. Qhov kev sib xyaw ua ke no yuav muab txoj hauv kev zoo dua los tswj cov mob mob hnyav.

 

Txhim Kho Kev Tiv Thaiv Kev Tiv Thaiv Cardiovascular
Cov tshuaj aspirin feem ntau yog siv rau cov kev tiv thaiv plawv vim nws cov tshuaj tua kab mob antiplateleties. Oleanicic Acid tau pom tias txhawm rau txhim kho lipid metabolism thiab txo cov oxidative kev nyuaj siab, muaj peev xwm ua tau cov txiaj ntsig ntawm aspirin cov txiaj ntsig. Qhov kev sib luag no yuav tau txais txiaj ntsig tshwj xeeb rau cov tib neeg uas muaj kev pheej hmoo ntawm cov kab mob plawv uas tseem xav tau kev tiv thaiv mob plab.

 

Qhov twg yuav yuav zoo-zoo aum acid hmoov?

 

Rau cov uas tab tom nrhiav kom sib xyaw ua ke ua kom muaj cov kua qaub rau hauv lawv txoj kev noj qab haus huv, so kom zoo. Ib qho ntawm cov khoom siv txhim khu kev qha ntawm cov ntshiab olanolic acid hmoov yogSab cij muajnoCov. Soft biTE biotech tshwj xeeb nyob rau hauv extraction nyob rau hauv extraction thiab kev tsim cov hwm ntawm cov nroj tsuag bioactactions, ua kom muaj kev coj dawb huv thiab kev ua tau zoo. Lawv cov oleanolic acid hmoov yog kev sim kom nruj rau cov paug thiab ua tau raws li cov qauv kev lag luam rau cov ntaub ntawv kev lag luam thiab khoom siv nutraceutical. Mus yuav cov oleanolic acid hmoov,Hu rau Sost Biotechlos ntawm lawv lub vev xaib lossis cov neeg siv khoom siv.

 

 

Ntawv Sawv cev

Liu, J. (1995). Pharmacology ntawm Oleanicic Acid thiab Ursolic Acid.Phau ntawv Journal ntawm Ethnoopharmacology, 49(2), 57-68.

Wang, X., Zhang, F., & Tian, ​​R. (2020). Oleanicic acid thiab nws derivatives nyob rau hauv kev kho mob ntawm mob hnyuv.Frontiers hauv Pharmacology, 11, 850.

Kim, DH, li al. (2014). Kev tiv thaiv cov teebmeem ntawm ancholicic acid on aspirin-induced pais plab mucosal puas tsuaj hauv cov nas.Phytomedicine, 21(8-9), 865-871.

Huang, L., & Gua T. (2021). Synergistic cuam tshuam ntawm cov aspirin thiab oozicic acid ntawm kev noj qab haus huv plawv: kev tshuaj xyuas.Tam sim no cov tshuaj nab tshuaj biotechnology, 22(4), 312-324.