Nws puas muaj kev nyab xeeb los noj qej dub?

Keeb kwm thiab Active Cheebtsam ntawm Dub qej Extract

Dub qej tsis yog ntau yam ntuj tsim, tab sis theej tsim los ntawm cov txheej txheem tswj kev fermentation nruj me ntsis. Cov qej tshiab yog fermented ntawm 60-80℃thiab 70-90% av noo rau 30-90 hnub. Thaum lub sijhawm txheej txheem no, cov khoom pungent hauv qej (xws li allicin) tau hloov mus rau hauv cov khoom siv ruaj khov dua, cov neeg sawv cev feem ntau yog S-allyl-L-cysteine ​​​​(SAC). Cov kev tshawb fawb tau pom tias SAC yog lub luag haujlwm tseem ceeb ntawmdub qej extract, thiab nws cov ntsiab lus ncaj qha txiav txim siab cov khoom lag luam lom neeg thiab cov nqi lag luam.

 

Nws puas muaj kev nyab xeeb los noj qej dub?

Kev kuaj mob toxicity
Ib txoj kev tshawb fawb txog kev mob rau qhov ncauj tawm los ntawm Kyoto Pharmaceutical University hauv Nyij Pooj xyoo 2018 qhia tias LD50 tus nqi ntawmdub qej extract(1.2% SAC cov ntsiab lus) hauv tus qauv nas yog ntau dua 5000 mg / kg lub cev qhov hnyav, koom nrog rau qhov ua tau zoo tsis yog - pawg tshuaj lom. Hloov mus rau 70kg cov neeg laus koob tshuaj, qhov no txhais tau hais tias txawm tias ib zaug noj ntawm 350g ntawm qej dub extract yuav tsis ua rau muaj kev phom sij txaus ntshai.

90-Hnub Subchronic Toxicity Test
Kev sim 90-hnub gavage ntawm nas ua los ntawm Kaus Lim Kauslim Lub Tsev Tshawb Nrhiav Khoom Noj hauv xyoo 2019, ua raws li OECD 408 cov lus qhia, pom tias kev noj txhua hnub ntawm 500 mg / kg lub cev hnyav ntawm qej dub extract (0.8% SAC) tsis pom muaj qhov tsis zoo (NOAEL), thiab cov ntshav biochemical thiab daim siab thiab lub raum histopathological ntsuas tsis sib txawv. Clinical Human Trials
Nyob rau hauv ib qho randomized, ob - qhov muag tsis pom, placebo- tswj kev sim luam tawm nyob rau hauv * Phau ntawv Journal ntawm Medicinal Food* xyoo 2021, 120 cov neeg mob uas muaj ntshav qab zib mellitus tau txais dub qej extract capsules (SAC 1.0 mg / kg lub cev hnyav) txhua hnub rau 12 lub lis piam. Cov txiaj ntsig tau pom:
Qhov nruab nrab tag nrho cov roj (cholesterol) poob los ntawm 8.3%
Tsawg-lipoprotein ntom ntom txo los ntawm 10.1%
Tsis muaj lub siab lossis lub raum ua haujlwm txawv txav, tsis xis nyob hauv plab, lossis kev tsis haum tshuaj.

Kev Ntsuam Xyuas Kev Sib Tham Txog Tshuaj
Hauv vitro CYP450 enzyme system kev sim ua los ntawm Free University of Berlin hauv 2022 tau lees paub tias cov qej dub extract ntawm qhov ntau ntawm 0.1-10 ug / mL tsis cuam tshuam rau kev ua haujlwm ntawm cov enzymes loj xws li CYP3A4 thiab CYP2D6, qhia tias muaj kev pheej hmoo tsawg heev ntawm kev cuam tshuam nrog cov tshuaj siv tshuaj ntau yam (suchy).

 

International Regulatory Framework thiab Kev Ua Raws Cai

US FDA Certification
Dub qej extract tau ntawv pov thawj raws li GRAS (Feem ntau Pom Zoo Raws Li Kev Nyab Xeeb) los ntawm FDA hauv 2016, nrog GRN tooj 635, tso cai rau nws siv los ua cov khoom noj khoom haus ntxiv, nrog kev pom zoo noj txhua hnub tsis pub ntau tshaj 1.5g (xws li 1% SAC).

EU EFSA Kev xav
European Food Safety Authority (EFSA) tau tshaj tawm cov kev xav hauv xyoo 2018, faib cov qej dub extract ua "cov khoom noj ib txwm siv," tso cai rau nws txoj kev ncig hauv EU lag luam yam tsis muaj kev pom zoo Novel Food.

Tuam Tshoj National Health Commission tshaj tawm
Raws li Kev Tshaj Tawm No. 4 ntawm National Health Commission ntawm Tuam Tshoj xyoo 2020, qej dub tau suav nrog hauv cov npe ntawm "cov khoom noj uas yog ob qho khoom noj thiab tshuaj," thiab nws cov extract tuaj yeem tswj tau raws li cov khoom noj khoom haus.

 

Cov ntsiab lus txaus ntshai thiab kev lag luam tsis xwm yeem

Txawm hais tias dub qej extract feem ntau muaj kev nyab xeeb, kev ua lag luam tseem nthuav tawm cov kev pheej hmoo hauv qab no:
Ua tsis tiav fermentation ua rau cov qib acrylamide ntau dhau (qee lub chaw tsim khoom me nce qhov kub siab tshaj 100℃kom luv lub voj voog ntau lawm)
Solvent residue (qee lub tuam txhab siv kev lag luam -qib ethanol rau kev rho tawm)
SAC cov ntsiab lus tsis raug (cov txheej txheem UV feem ntau muaj qhov yuam kev txog li ± 30%)
Kev kis kab mob microbial (kev cob qhia fermentation tsis ua raws li GMP tus qauv, thiab kuaj pom aflatoxin B1)

Yuav Ua Li Cas Tshawb Nrhiav Kev Nyab Xeeb?

Ua tiav ntawm Certification System
Ua ntej cov tuam txhab uas tau txais ISO 22000, HACCP, USDA Organic, Kosher, thiab Halal ntawv pov thawj, ua kom tag nrho traceability ntawm raw khoom mus rau cov khoom tiav.

Kev Tshawb Fawb Txog Kev Ntsuas Cov Peev Xwm
Xav kom cov neeg muag khoom muab:
HPLC chromatogram rau txhua pawg (SAC cov ntsiab lus raug rau 0.01%)
Thib peb-cov ntaub ntawv qhia txog kev ntsuas cov hlau hnyav (lead Tsawg dua lossis sib npaug li 0.5 ppm, arsenic Tsawg dua lossis sib npaug li 0.3 ppm, cadmium Tsawg dua lossis sib npaug li 0.2 ppm)
Microbial tswj ntsuas (tag nrho cov kab mob suav tsawg dua lossis sib npaug ntawm 1000 CFU / g, pwm thiab cov poov xab Tsawg dua lossis sib npaug rau 100 CFU / g)

Txheej txheem Patent Protection
Cov tuam txhab uas tsis muaj -kub enzymatic fermentation patents (kub tswj ntawm 60 ± 2 degree, av noo 75 ± 5%) tuaj yeem ua rau SAC hloov pauv ntau dua 40%, thaum txo cov acrylamide ntau lawm rau<50 μg/kg (EU limit 750 μg/kg).

 

Vim li cas thiaj xaiv Xi'an Sost Biotech Co., Ltd.?

Raws li lub teb chaws siab - thev naus laus zis kev lag luam tshwj xeeb hauv kev cog qoob loo rau 18 xyoo, Sost Biotech tau tsim kom muaj kev sib tw tsis sib xws hauv thaj teb ntawm qej dub extract:

Kev nqis peev Hardware
Nruab nrog 2 German-ntsuas qis-kub fermentation ntau lawm kab (ib pob muaj peev xwm ntawm 5 tons)
Nruab nrog US Waters UPLC nrhiav kom tau platform, nrog rau SAC kev kuaj pom qhov tsawg li 0.02% thiab qhov tseeb ntawm ± 1.5% (kev lag luam nruab nrab ± 5%)
Kev ywj pheej CNAS tau lees paub lub chaw kuaj mob, muaj peev xwm tshaj tawm cov ntaub ntawv xeem nrog ilac-MRA thoob ntiaj teb kev sib nrig sib lees paub

Software zog
Koom nrog hauv kev tsim cov qauv kev lag luam rau "Black Garlic Extract"
Tau txais ib lub teb chaws invention patent rau dub qej fermentation txheej txheem
Ua tiav US FDA lub Hoobkas rau npe thiab EU tshiab zaub mov ua ntej- kev ntsuas

Kev cog lus zoo
Txhua batch ntawm dub qej extract muab:
① Ua kom tiav HPLC tus ntiv tes (12 tus yam ntxwv ncov sib npaug ntawm tus qauv qauv nrog qhov zoo sib xws ntawm Ntau dua lossis sib npaug rau 98%)
② Daim ntawv tshaj tawm kev xeem los ntawm thoob ntiaj teb muaj npe SGS lossis Eurofins (ob hom lus hauv Suav thiab Askiv)
③ Traceable QR code (scan saib cov khoom siv raw, fermentation batch, rho tawm hnub, thiab cov neeg ua haujlwm kuaj)

Customized Services
Rau cov neeg siv khoom sib txawv, peb tuaj yeem muab:
Gradient specifications ntawm SAC cov ntsiab lus los ntawm 0.5% mus rau 3.0%
Dej-soluble/lipid-soluble dual formulations
Ntau - specification ntim los ntawm 1kg aluminium foil hnab rau 25kg cardboard nruas
Cov qauv dawb (50g kuaj pob) thiab kev tsim qauv kev txhawb nqa

Tiv tauj peb
Yog tias koj tab tom nrhiav kom muaj kev nyab xeeb, ua raws, thiab muaj zog heev dub qej extract raw cov ntaub ntawv, Xi'an Sost Biotech Co., Ltd. yuav yog koj tus khub txhim khu kev qha tshaj plaws.
Email:info@sostherbusa.com(Kev tshaj lij teb hauv 24 teev)
Lub Vev Xaib: www.sosterb.com ua(COA, kev qhia tshwj xeeb, thiab cov ntaub ntawv tswj hwm muaj rau rub tawm)

Peb cog lus tias: Tag nrho cov ntaub ntawv ntsuam xyuas txhawb nqa thib peb - tog rov - kev sim, thiab cov khoom tsis tsim nyog tuaj yeem xa rov qab lossis sib pauv yam tsis muaj xwm txheej!

 

Cov ntaub ntawv
[1] Kim, S., et al. (2017). "Kev txheeb xyuas txoj kev siv tau rau S-Allyl-L-Cysteine ​​​​hauv cov qej dub los ntawm HPLC-DAD." Phau ntawv Journal of Food Composition and Analysis, 62:184-190.
[2] Tsubura, A., et al. (2018). "Kev tshawb nrhiav qhov ncauj toxicity ntawm tus qauv dub qej extract hauv ICR nas." Food and Chemical Toxicology, 111:658-663.
[3] Park, JH, et al. (2019). "90-hnub subchronic toxicity ntsuam xyuas ntawm fermented dub qej nyob rau hauv Sprague-Dawley nas." Regulatory Toxicology thiab Pharmacology, 107:104-111.
[4] Chen, S., et al. (2021). "Cov nyhuv Hypolipidemic ntawm cov laus dub qej extract rau cov neeg laus uas muaj mob me me hypercholesterolemia: Ib qho randomized, ob npaug - dig muag, placebo- tswj kev sim." Phau ntawv Journal of Medicinal Food, 24(3): 1-8.
[5] Muller, L., et al. (2022). "Kev ntsuam xyuas hauv vitro ntawm cytochrome P450-cov tshuaj ntsuab-tshuaj sib cuam tshuam muaj peev xwm ntawm cov qej dub ntxiv." Phytomedicine, 102:154–160.